Exploring how a neurotransmitter affects memory problems in older adults with schizophrenia
Official title: Determining the relationship between NAAG and memory deficits in schizophrenia in mid- to late- life
Funded at Johns Hopkins University · NIH-11129119 · Data updated 2026-11-12
This study is looking at how a substance called NAAG might help improve memory problems in older adults with schizophrenia, and it aims to find ways to boost NAAG levels to support better brain function and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 12, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $804,690 |
| NIH project number | 1R01MH137602-01A1 |
| Project ID | NIH-11129119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with schizophrenia who are experiencing cognitive deficits.
✕Less likely to help
Patients who are not diagnosed with schizophrenia or who are younger than 21 years old may not benefit from this research.
What this research studies
This research investigates the role of N-acetyl-aspartyl-glutamate (NAAG) in memory deficits experienced by older adults with schizophrenia. By focusing on the relationship between NAAG levels and cognitive function, the study aims to understand how increasing NAAG through the inhibition of a specific enzyme could improve memory symptoms. The research will utilize both animal models and human data to explore the effects of NAAG modulation on brain function and memory performance. This could lead to new therapeutic strategies for enhancing cognitive abilities in this patient population.
Why it matters
Potential benefit: If successful, this research could lead to improved memory function and quality of life for older adults suffering from schizophrenia.
How similar studies have gone: Previous research has shown promising results in animal models regarding the modulation of NAAG and its effects on memory, but human data is limited and this approach is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Bigos, Kristin L — Johns Hopkins University
- Study coordinator: Bigos, Kristin L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.