Exploring how a low-fat, high-fiber diet may help reduce brain damage after injury.
Official title: Investigating the potential impact of a low-fat high fiber diet in limiting TBI-induced neurodegenerative and inflammatory changes.
Funded at Rowan University School/osteopathic Med · NIH-10876125 · Data updated 2026-11-12
This study is looking at how a low-fat, high-fiber diet might help improve recovery for people who have had a traumatic brain injury by reducing inflammation and protecting the brain, and it's being tested in mice that mimic some health issues related to brain injuries.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | July 19, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $498,713 |
| NIH project number | 1R15NS137260-01 |
| Project ID | NIH-10876125 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and may also have chronic cardiovascular conditions.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or do not have related cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the effects of a low-fat, high-fiber diet on reducing neurodegenerative and inflammatory changes caused by traumatic brain injury (TBI). Using a mouse model that simulates chronic cardiovascular disease and TBI, the study compares the outcomes of this diet against a standard high-fat, low-fiber diet. The goal is to understand how dietary changes can influence the breakdown of the blood-brain barrier and the immune response following brain injury. By focusing on dietary interventions, the research aims to find new ways to support recovery in TBI survivors.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that significantly improve recovery outcomes for individuals with traumatic brain injuries.
How similar studies have gone: While dietary interventions for TBI are being explored, this specific approach using a low-fat, high-fiber diet in the context of TBI and cardiovascular disease is relatively novel.
Where this research is happening
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Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Acharya, Nimish Kumar — Rowan University School/osteopathic Med
- Study coordinator: Acharya, Nimish Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.