Exploring how a lack of NAD affects a genetic disorder related to tryptophan metabolism
Official title: Understanding the Role of NAD Deficiency in a Mendelian Disorder of Tryptophan Metabolism
Funded at Baylor College of Medicine · NIH-11069580 · Data updated 2026-11-12
This study is looking into how certain genetic factors can cause low levels of a vital nutrient called NAD, which may lead to birth defects and developmental problems, and it will also check if adding niacin to the diet can help improve these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 6, 2025 |
| Project end | January 5, 2028 |
| Funding year | 2025 |
| Award (this year) | $46,174 |
| NIH project number | 1F31HD115407-01A1 |
| Project ID | NIH-11069580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital anomalies, developmental delays, or a family history of recurrent miscarriages linked to NAD deficiencies.
✕Less likely to help
Patients without genetic disorders related to tryptophan metabolism or those not exhibiting symptoms of NAD deficiency may not benefit from this research.
What this research studies
This research investigates the genetic causes of congenital nicotinamide adenine dinucleotide (NAD) deficiencies, particularly focusing on how disruptions in the kynurenine pathway can lead to various birth defects and developmental issues. By studying mouse models with specific genetic variants, the research aims to understand the relationship between low NAD levels and the resulting health conditions. The study will also explore whether dietary niacin supplementation can help mitigate some of the negative effects associated with these deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to new dietary interventions that improve health outcomes for individuals affected by congenital NAD deficiencies.
How similar studies have gone: While the specific genetic variant being studied has not been previously associated with congenital NAD deficiencies, research into similar metabolic pathways has shown promise in understanding related disorders.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Aceves, Nathalie Marie — Baylor College of Medicine
- Study coordinator: Aceves, Nathalie Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.