Exploring how a genetic variant affects Alzheimer's disease risk
Investigating the role of an EIF2B3 variant as an Alzheimer's disease risk modifier
['FUNDING_FELLOWSHIP'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11054693
This study is looking at how a certain gene might affect the risk of developing Alzheimer's disease, especially for people who have a specific gene variant called APOE4, to better understand how these genetic factors influence the progression of the disease.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11054693 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific genetic variant in the EIF2B3 gene and its potential to modify the risk of developing Alzheimer's disease, particularly among individuals who carry the APOE4 gene variant. By analyzing genetic data from individuals with varying ages of onset for cognitive impairment, the study aims to identify how this variant influences the severity and progression of Alzheimer's. The research employs genome-wide association studies to uncover genetic factors that may contribute to differences in clinical outcomes among APOE4 carriers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are APOE4 carriers and have a family history of Alzheimer's disease.
Not a fit: Patients who do not carry the APOE4 variant or have no family history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for predicting and managing Alzheimer's disease risk in genetically susceptible individuals.
How similar studies have performed: Previous research has successfully identified genetic factors associated with Alzheimer's disease risk, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARRETTI, FRANCESCA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: GARRETTI, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome