Exploring how a cannabinoid receptor can reduce inflammation in the breast during breastfeeding.
Official title: Investigating the therapeutic potential of CB2 in modulation of inflammation in the mammary gland during lactation
Funded at University of Puerto Rico at Aguadilla · NIH-10514546 · Data updated 2026-11-12
This study is looking at how a specific receptor in the body might help reduce inflammation caused by mastitis, a painful condition some women experience while breastfeeding, to find ways to make breastfeeding easier and more comfortable.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico at Aguadilla NIH-funded |
| Lab location | 1 site (Aguadilla, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $282,665 |
| NIH project number | 1R15HD109919-01 |
| Project ID | NIH-10514546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postpartum women experiencing symptoms of mastitis or inflammation in the breast.
✕Less likely to help
Patients who are not postpartum or do not experience mastitis may not benefit from this research.
What this research studies
This research investigates the role of the cannabinoid type 2 (CB2) receptor in reducing inflammation associated with mastitis, a condition that can occur in women during the early weeks of breastfeeding. The study aims to understand how activating this receptor can decrease harmful inflammatory cytokines and reactive oxygen species that damage mammary tissue and affect milk production. By utilizing various agonists that activate CB2, the research seeks to identify potential therapeutic strategies to alleviate inflammation and support breastfeeding.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help women maintain breastfeeding by reducing inflammation and associated complications.
How similar studies have gone: Previous studies have shown promising results regarding the anti-inflammatory effects of CB2 activation in chronic inflammatory conditions, suggesting potential for success in this area.
Where this research is happening
-
University of Puerto Rico at Aguadilla
Aguadilla, United States Active
Researchers
- Principal investigator: Perez Laspiur, Juliana — University of Puerto Rico at Aguadilla
- Study coordinator: Perez Laspiur, Juliana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.