Exploring hidden natural products in bacteria for health benefits
From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural Products
This study is looking at special substances made by bacteria to find new medicines that could help people stay healthy, especially by using low doses of antibiotics to wake up these hidden compounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10765436 on NIH RePORTER |
What this research studies
This research investigates the natural products encoded in bacterial genomes, focusing on their structures, functions, and therapeutic uses. By developing new methods to stimulate the production of previously inactive natural products, particularly through the use of low-dose antibiotics, the research aims to uncover novel compounds that could benefit human health. The study also explores the role of these metabolites in microbial interactions and their potential applications in treating diseases. Overall, the research seeks to expand our understanding of the chemical diversity present in the human microbiome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from novel antibiotic treatments or those interested in the role of the microbiome in health.
Not a fit: Patients with conditions unrelated to bacterial infections or microbiome health may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new antibiotics and therapeutic agents that improve patient health outcomes.
How similar studies have performed: Previous research has shown success in uncovering novel natural products from microbial sources, indicating a promising avenue for further exploration.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Seyedsayamdost, Mohammad R — Princeton University
- Study coordinator: Seyedsayamdost, Mohammad R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.