Exploring heart muscle structure and function using advanced imaging and fluid dynamics
Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and Function
This study is looking at how a heart condition called non-compaction cardiomyopathy affects the heart's structure and function, using advanced imaging and computer models to better understand blood flow and heart muscle movement, which could help find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10847340 on NIH RePORTER |
What this research studies
This research investigates a heart condition known as non-compaction cardiomyopathy (NCC), which affects the structure of heart muscle and can lead to serious complications like arrhythmias. By integrating advanced imaging techniques with computational fluid dynamics, the study aims to understand how blood flow and heart muscle contraction interact to influence heart development and function. The research utilizes in silico analysis to explore the biomechanical forces at play during heart muscle formation and how these forces may be altered in patients with NCC. This approach could lead to new insights into the mechanisms behind this condition and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with non-compaction cardiomyopathy or those with congenital heart defects.
Not a fit: Patients without any cardiac conditions or those who do not have a genetic predisposition to non-compaction cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve understanding and treatment options for patients with non-compaction cardiomyopathy and related heart conditions.
How similar studies have performed: Previous research has shown promise in using computational fluid dynamics to study cardiac conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsiai, Tzung K — University of California Los Angeles
- Study coordinator: Hsiai, Tzung K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.