Exploring genetics and microbiome interactions in inflammatory bowel disease among minority populations.
Understanding genetic architecture and host-microbiome interactions in Inflammatory bowel disease in under-represented minority populations and in patients with unmet medical need.
This study is looking at how genes and gut bacteria affect inflammatory bowel disease (IBD) in African American and Hispanic patients, to find out why standard treatments might not work as well for them and to discover new ways to help.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10909896 on NIH RePORTER |
What this research studies
This research investigates the genetic factors and microbiome interactions that contribute to inflammatory bowel disease (IBD), particularly in under-represented minority populations such as African Americans and Hispanics. The study aims to understand why these populations may not respond well to standard treatments and seeks to identify specific genetic variants that influence disease progression and treatment efficacy. By utilizing advanced biomarker-based techniques, the research will analyze genetic data and microbiome profiles to uncover potential therapeutic targets. Patients may be involved in providing samples and data to help elucidate these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from under-represented minority groups, particularly those diagnosed with inflammatory bowel disease.
Not a fit: Patients who do not have inflammatory bowel disease or those from populations already well-represented in IBD research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for inflammatory bowel disease in minority populations.
How similar studies have performed: While research on IBD has been extensive, this specific focus on minority populations and their unique genetic and microbiome interactions is relatively novel and underexplored.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mcgovern, Dermot Patrick — Cedars-Sinai Medical Center
- Study coordinator: Mcgovern, Dermot Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.