Exploring genetic weaknesses in breast cancer
MSK SPORE in Genomic Instability in Breast Cancer
This study is looking at how certain genetic issues in breast cancer can help us create better treatments, so we can find ways to fight the disease more effectively and improve outcomes for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10902106 on NIH RePORTER |
What this research studies
This research investigates the genetic instability found in breast cancer, focusing on three main areas: deficiencies in homologous recombination, chromosomal instability, and the role of APOBEC mutagenesis. By understanding these genetic vulnerabilities, the research aims to develop targeted therapies that exploit these weaknesses, potentially leading to more effective treatments for breast cancer patients. The approach includes studying how these genetic factors contribute to cancer progression and drug resistance, with the goal of improving patient outcomes through novel therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those exhibiting genomic instability or resistance to current therapies.
Not a fit: Patients with early-stage breast cancer who do not exhibit genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for breast cancer that specifically target its genetic vulnerabilities.
How similar studies have performed: Previous research has shown promising results in targeting genetic vulnerabilities in cancer, particularly with therapies like PARP inhibitors for homologous recombination deficiency, indicating potential for success in this area.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Powell, Simon N. — Sloan-Kettering Inst Can Research
- Study coordinator: Powell, Simon N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.