Exploring genetic links between autism and schizophrenia
Official title: A Genetics-First Approach to Shared Risk in Neurodevelopmental Disorders
Funded at Columbia University Health Sciences · NIH-10808679 · Data updated 2026-11-12
This study is looking at how certain genes might affect autism and how they relate to schizophrenia, with the goal of finding unique genetic traits that could help us understand different types of autism better and create more personalized support for individuals with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 19, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $194,400 |
| NIH project number | 1K23MH132874-01A1 |
| Project ID | NIH-10808679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with a family history of schizophrenia or cognitive impairments.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those who do not carry the genetic variants of interest may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to autism spectrum disorder (ASD) and their overlap with schizophrenia (SCZ). By utilizing a large genetic database of over 50,000 individuals with autism, the study aims to identify rare genetic variants that may influence cognitive functions and associated behaviors. The approach focuses on understanding how these genetic variants can help categorize different subgroups within ASD, potentially leading to more tailored interventions. Patients may be assessed for cognitive systems and psychopathology related to these genetic factors.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with autism by identifying specific genetic profiles.
How similar studies have gone: Previous research has shown promise in using genetic approaches to understand neurodevelopmental disorders, indicating that this methodology could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Jutla, Amandeep — Columbia University Health Sciences
- Study coordinator: Jutla, Amandeep
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.