Exploring genetic factors that influence schizophrenia
Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
This study is looking at how certain genetic differences in parts of DNA that don't code for proteins might influence brain functions related to schizophrenia, with the goal of finding new ways to improve diagnosis and treatment for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11015067 on NIH RePORTER |
What this research studies
This research investigates how genetic variations, particularly in noncoding regions of DNA, affect the functioning of regulatory elements in the brain related to schizophrenia. By utilizing advanced techniques in functional genomics and epigenome editing, the study aims to identify and validate these regulatory elements and their variants in neuronal cells. The approach combines interdisciplinary expertise to bridge the gap in understanding how these genetic factors contribute to psychiatric disorders, potentially leading to better diagnostic and treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia or those at risk of developing the disorder.
Not a fit: Patients with schizophrenia who do not have identifiable genetic variations or those with other unrelated psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with schizophrenia.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to psychiatric disorders, indicating that this approach could yield significant insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Crawford, Gregory E — Duke University
- Study coordinator: Crawford, Gregory E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.