Exploring genetic factors that contribute to Alzheimer's disease
Quantitative Genetic Models for Exploring Missing Heritability of Alzheimer's Disease
This study is looking into the genes that might increase the risk of Alzheimer's disease, hoping to find new ways to help treat it and identify people who could benefit from early help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10144547 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of Alzheimer's disease (AD) by developing advanced quantitative models to identify genetic risk factors. It aims to uncover novel genetic loci associated with AD, which could lead to new treatment targets and help identify individuals at risk for early intervention. The study utilizes data from previous genome-wide association studies (GWAS) and incorporates various biological data types to enhance gene detection. By addressing the limitations of current GWAS, this research seeks to provide deeper insights into the genetic basis of AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with non-genetic forms of dementia or those without a family history of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options and preventive strategies for Alzheimer's disease.
How similar studies have performed: Previous research using genome-wide association studies has shown promise in identifying genetic factors for various diseases, suggesting that this approach could yield valuable insights for Alzheimer's disease as well.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Epstein, Michael Philip — Emory University
- Study coordinator: Epstein, Michael Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.