Exploring genetic factors in very early onset inflammatory bowel disease
Integration of genomics and transcriptomics to investigate biological pathways in very early onset IBD
This study is looking at the genes and cell changes that might cause very early onset inflammatory bowel disease (IBD) in kids under six, to help us understand the condition better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11086015 on NIH RePORTER |
What this research studies
This research investigates the genetic and transcriptomic factors contributing to very early onset inflammatory bowel disease (VEO-IBD) in children diagnosed before the age of six. By utilizing whole genome sequencing and transcriptome analysis, the study aims to identify causal genetic variants that may lead to this aggressive form of IBD. The approach includes examining gene expression changes at a cellular level to better understand the underlying biological pathways involved. This comprehensive analysis could provide insights into the disease's pathogenesis and inform potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under six years old who have been diagnosed with very early onset inflammatory bowel disease.
Not a fit: Patients diagnosed with IBD after the age of six or those with other forms of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and targeted therapies for children suffering from very early onset IBD.
How similar studies have performed: Previous research has shown success in identifying genetic factors in other forms of IBD, suggesting that this approach may yield valuable insights for VEO-IBD as well.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kelsen, Judith Rachel — Children's Hosp of Philadelphia
- Study coordinator: Kelsen, Judith Rachel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.