Exploring genetic factors in intellectual and developmental disorders
Official title: Identifying transcriptomic and epigenomic convergence in intellectual and developmental disorders
Funded at Baylor College of Medicine · NIH-10933406 · Data updated 2026-11-12
This study is looking at how certain genes might affect brain function and contribute to intellectual and developmental disabilities, with the hope of finding new ways to help people with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 5DP5OD036131-02 |
| Project ID | NIH-10933406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with intellectual and developmental disabilities or those with a family history of such conditions.
✕Less likely to help
Patients with IDDs caused by non-genetic factors or those not associated with the COMPASS methyltransferase genes may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors contributing to intellectual and developmental disabilities (IDDs) by focusing on a specific group of genes known as COMPASS methyltransferases. Using advanced techniques like CRISPR interference, the study aims to understand how changes in these genes affect brain cell function. By analyzing human-derived neurons, researchers will identify common pathways that may lead to IDDs, potentially paving the way for new therapeutic strategies. The goal is to group IDD-associated genes based on shared mechanisms rather than studying each gene individually.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for various intellectual and developmental disorders by targeting shared genetic pathways.
How similar studies have gone: Previous research has shown promise in using genetic and epigenetic approaches to understand complex disorders, suggesting that this methodology could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Dhindsa, Ryan — Baylor College of Medicine
- Study coordinator: Dhindsa, Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.