Exploring genetic elements linked to Alzheimer's disease and healthy aging
Official title: Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging
Funded at Washington University · NIH-10865118 · Data updated 2026-11-12
This study is looking at how certain genetic pieces might influence the development of Alzheimer's disease and aging by examining brain samples from people with genetic links to the condition, with the hope of finding new ways to help treat or prevent the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,809,944 |
| NIH project number | 5R01AG078964-03 |
| Project ID | NIH-10865118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 21 and older who have genetic mutations associated with Alzheimer's disease or are at risk due to family history.
✕Less likely to help
Patients without any genetic predisposition to Alzheimer's disease or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of specific genetic elements, known as transposable elements, in the development of Alzheimer's disease and the aging process. By analyzing human brain tissues and using advanced genomic techniques, the team aims to identify how these elements affect brain cell function and contribute to Alzheimer's pathology. The study will involve both direct analysis of brain samples from individuals with genetic mutations related to Alzheimer's and the use of engineered cells to understand the underlying mechanisms. This multidisciplinary approach seeks to uncover new insights into the disease and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in Alzheimer's disease, but this specific approach focusing on transposable elements is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cruchaga, Carlos — Washington University
- Study coordinator: Cruchaga, Carlos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.