Exploring genetic changes in brain tissue to understand Alzheimer's disease
Using long-range technologies as a multi-omic approach to understand Alzheimer’s disease in brain tissue
This study is looking at the tiny changes in genes and RNA in brain tissue to better understand how Alzheimer's disease develops, which could help find new ways to diagnose and treat the condition for patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10850701 on NIH RePORTER |
What this research studies
This research aims to uncover the specific molecular changes that contribute to Alzheimer's disease by using advanced DNA mapping and sequencing techniques. By analyzing brain tissue, the study seeks to identify genetic variants and RNA modifications that may play a role in the disease's progression. This approach focuses on understanding the mechanisms behind Alzheimer's, which could lead to earlier diagnosis and targeted therapies. Patients may benefit from insights that could inform future treatment options and diagnostic tools.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease or those with early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any familial or genetic risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for Alzheimer's disease.
How similar studies have performed: Previous research using similar genetic and molecular approaches has shown promise in understanding neurodegenerative diseases, suggesting potential for success in this study.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Ebbert, Mark T W — University of Kentucky
- Study coordinator: Ebbert, Mark T W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.