Exploring genetic causes of congenital hydrocephalus
Official title: Understanding the mechanisms of congenital hydrocephalus using genomic sequencing approaches
Funded at University of Alabama at Birmingham · NIH-10789333 · Data updated 2026-11-12
This study is looking at congenital hydrocephalus, a condition where fluid builds up in the brain, to find out if certain genes play a role in it, which could help doctors better understand and treat kids with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 11, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $392,855 |
| NIH project number | 1R21NS135321-01 |
| Project ID | NIH-10789333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with congenital hydrocephalus, particularly those with unexplained cases.
✕Less likely to help
Patients with congenital hydrocephalus caused solely by known extrinsic factors, such as infections or hemorrhage, may not benefit from this research.
What this research studies
This research investigates congenital hydrocephalus, a condition where cerebrospinal fluid accumulates in the brain, leading to various health issues. The team will use advanced genomic sequencing techniques to identify genetic variations that may contribute to this condition, aiming to improve understanding and treatment options. By analyzing both germline and somatic tissues, the researchers hope to uncover new genetic factors that have not yet been identified. This could lead to better diagnostic tools and targeted therapies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for children with congenital hydrocephalus.
How similar studies have gone: Previous research has shown promise in using genomic approaches to uncover genetic factors in other congenital conditions, suggesting potential success for this novel approach.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Chong, Zechen — University of Alabama at Birmingham
- Study coordinator: Chong, Zechen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.