Exploring genetic and molecular factors linked to Alzheimer's disease
Integrating Alzheimer's disease GWAS with proteomic and metabolomic QTL data
This study is looking at how our genes and certain proteins in the body might be linked to Alzheimer's disease, with the hope of finding new ways to help diagnose and treat the condition earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10875729 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular underpinnings of Alzheimer's disease by integrating existing data from genome-wide association studies (GWAS) with proteomic and metabolomic data. The goal is to identify specific proteins and metabolites that may play a causal role in the development of Alzheimer's. By employing advanced statistical methods, the research aims to enhance the understanding of how genetic variations influence the risk of Alzheimer's and potentially lead to new therapeutic targets. Patients may benefit from insights that could inform early diagnosis and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease or those with early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease.
How similar studies have performed: Previous research using similar integrative approaches has shown promise in identifying causal factors for complex diseases, suggesting potential for success in this study.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Pan, Wei — University of Minnesota
- Study coordinator: Pan, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.