Exploring gene mutations linked to skin conditions in Latinx patients
Official title: Investigation of Filaggrin Gene Mutations among Latinx patients with Atopic Dermatitis
Funded at University of Pennsylvania · NIH-10909292 · Data updated 2026-11-12
This study is looking at how certain gene changes might affect the severity of atopic dermatitis in Latinx patients, with the hope of improving how we diagnose and manage this skin condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 17, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $172,709 |
| NIH project number | 5K23AR081984-02 |
| Project ID | NIH-10909292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Latinx individuals diagnosed with atopic dermatitis, particularly those experiencing severe symptoms.
✕Less likely to help
Patients who do not have atopic dermatitis or those from non-Latinx backgrounds may not benefit from this research.
What this research studies
This research investigates the role of specific gene mutations in the development of atopic dermatitis among Latinx patients. By examining the filaggrin gene, which is known to affect skin barrier function, the study aims to understand how genetic variations and ancestry contribute to the severity of this chronic skin condition. The research will involve collecting genetic data from participants and analyzing how these factors interact with environmental influences. Ultimately, the goal is to enhance diagnostic and management strategies for atopic dermatitis in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for atopic dermatitis in Latinx patients.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in atopic dermatitis, but this specific focus on Latinx populations is relatively novel.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Chiesa Fuxench, Zelma Charlotte — University of Pennsylvania
- Study coordinator: Chiesa Fuxench, Zelma Charlotte
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
-
SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
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SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
-
Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
-
Personalized predictions for how atopic dermatitis may progress in kids and teens
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.