Exploring factors that help regenerate nerve cells in the gut as we age
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11000383
This study is looking at how things that help young people can also boost nerve cell growth in the gut for adults and older folks, with the hope of finding new ways to improve digestive health as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11000383 on ClinicalTrials.gov |
What this research studies
This research investigates how certain protective factors present during youth can stimulate the growth of nerve cells in the gut, particularly in adults and the elderly. The study focuses on the Enteric Nervous System, which controls gut motility and is crucial for digestive health. By understanding how these juvenile protective factors can be reintroduced or enhanced in adults, the research aims to address age-related decline in gut function and neurogenesis. Patients may benefit from insights that could lead to new treatments for gut disorders associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults and elderly individuals experiencing gut motility issues or related disorders.
Not a fit: Patients with acute gastrointestinal conditions unrelated to neurogenesis or aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve gut health and function in older adults.
How similar studies have performed: Previous research has shown promise in using juvenile protective factors to enhance neurogenesis, suggesting potential for success in this approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOFF, LOYAL ANDREW — JOHNS HOPKINS UNIVERSITY
- Study coordinator: GOFF, LOYAL ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.