Exploring factors that affect the hidden HIV reservoir, including drug use
A machine learning framework for understanding impacts on the HIV latent reservoir size, including drugs of abuse
This research looks at how different factors, including recreational drug use, might influence the hidden HIV reservoir in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11125944 on NIH RePORTER |
What this research studies
The biggest challenge in curing HIV is a hidden group of infected cells, called the latent reservoir, that current treatments can't get rid of. We don't fully understand what makes this reservoir grow or shrink, or how things like recreational drug use might play a role. This project uses advanced computer modeling to help us learn more about how cannabinoid use, which is common among people with HIV, might affect the immune system and the size of this hidden HIV reservoir. Our goal is to gain a deeper understanding of these complex interactions.
Who could benefit from this research
Good fit: This research is relevant to individuals living with HIV, especially those who may use recreational drugs, as it seeks to understand factors influencing the latent virus.
Not a fit: Patients who do not have HIV or are not concerned with the latent reservoir may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help us better understand the HIV reservoir, potentially leading to new strategies to reduce its size and move closer to a cure.
How similar studies have performed: While the importance of the HIV reservoir is known, little is understood about the specific biological factors and drug effects on it, making this a novel area of inquiry requiring new computational tools.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Rudin, Cynthia — Duke University
- Study coordinator: Rudin, Cynthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.