Exploring deep brain stimulation techniques for lasting relief in Parkinson's disease
DBS Protocols for Long-Lasting Therapeutic Benefit in Mouse and Primate Models of Parkinson's Disease
['FUNDING_R01'] · CARNEGIE-MELLON UNIVERSITY · NIH-10812330
This study is looking at a new way to use deep brain stimulation to help people with Parkinson's disease feel better for a longer time by targeting specific brain cells, and it's testing this approach in both mice and primates.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CARNEGIE-MELLON UNIVERSITY (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10812330 on ClinicalTrials.gov |
What this research studies
This research investigates advanced deep brain stimulation (DBS) techniques aimed at providing long-lasting therapeutic benefits for patients with Parkinson's disease. By utilizing a modified DBS protocol known as coordinated reset (CR-DBS), the study seeks to enhance the duration of symptom relief beyond the immediate effects of traditional DBS. The approach involves targeting specific neuronal subpopulations in the brain to improve motor function and potentially alleviate the underlying dysfunction associated with Parkinson's disease. The research employs both mouse and primate models to explore the effectiveness of these interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with advanced Parkinson's disease who are experiencing motor symptoms.
Not a fit: Patients with early-stage Parkinson's disease or those who do not respond to deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Parkinson's disease that provide longer-lasting relief from motor symptoms.
How similar studies have performed: Previous research has shown promise with similar DBS techniques, but this specific approach is novel and aims to enhance existing methods.
Where this research is happening
PITTSBURGH, UNITED STATES
- CARNEGIE-MELLON UNIVERSITY — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GITTIS, ARYN HILARY — CARNEGIE-MELLON UNIVERSITY
- Study coordinator: GITTIS, ARYN HILARY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.