Exploring cancer mechanisms using data from various mammal species
Administrative Supplement - Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers
This study is looking at how cancer develops and grows by comparing tumors from different animals, with the hope that the findings will help create better treatments for people with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10927488 on NIH RePORTER |
What this research studies
This research investigates the underlying factors that contribute to cancer development and progression by studying tumors across different mammalian species. By creating a comprehensive database of mammalian tumors and utilizing advanced machine learning techniques, the project aims to identify patterns of cancer emergence and resistance. This integrative approach combines genomic data from both humans and animals to uncover new insights into cancer biology, potentially leading to novel therapeutic targets. Patients may benefit from the findings as they could inform more effective cancer treatments based on evolutionary insights.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with rare cancers, particularly those under 21 years old.
Not a fit: Patients with common cancers or those not diagnosed with cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating rare human cancers.
How similar studies have performed: Other research has shown promise in using comparative oncology approaches, suggesting potential for success in this novel application.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Graim, Kiley — University of Florida
- Study coordinator: Graim, Kiley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.