Exploring brain network changes in neurodegenerative diseases linked to TDP-43
Understanding dynamics of brain network in TDP-43 related neurodegeneration
This project aims to understand how brain networks change in conditions like Alzheimer's and ALS by studying a specific protein in animal models.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11189690 on NIH RePORTER |
What this research studies
This project looks at a protein called TDP-43, which is often found in the wrong place in the brains of people with diseases like Alzheimer's, ALS, and frontotemporal dementia. We believe that when TDP-43 is misplaced, it causes brain cells to lose their normal function, leading to these conditions. To understand how these diseases progress, we are using special mouse models where the TDP-43 protein is altered. We will use advanced imaging techniques to watch how brain circuits change over time in these mice and develop new computer tools to analyze these complex patterns.
Who could benefit from this research
Good fit: This foundational research does not directly involve human patients, but future studies building on this work would be relevant for individuals with Alzheimer's disease, ALS, or frontotemporal dementia.
Not a fit: Patients without neurodegenerative conditions linked to TDP-43 mislocalization would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how neurodegenerative diseases develop, potentially guiding the creation of new treatments.
How similar studies have performed: While the role of TDP-43 in neurodegeneration is established, this project develops novel computational methods to analyze dynamic brain network changes in animal models, which is a less explored area.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Chen, Rong — University of Maryland Baltimore
- Study coordinator: Chen, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.