Exploring brain function changes in people with long-term effects of COVID-19

Understanding Circuit Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection

NIH-funded research Yale University · NIH-11023241

This study is looking at how COVID-19 might affect your brain and mental health, like causing memory problems or anxiety, and it's for people who have had COVID-19 and want to understand their symptoms better.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-11023241 on NIH RePORTER

What this research studies

This research investigates the neuropsychiatric symptoms experienced by individuals who have had COVID-19, such as cognitive impairment, anxiety, and autonomic dysfunction. By utilizing the resources of the NeuroCOVID Clinic and The COVID Mind Study at Yale, the research aims to understand how these symptoms are linked to changes in brain function. Participants will undergo neuroimaging and cognitive testing to identify biological markers associated with their symptoms. The goal is to provide a clearer understanding of the brain's circuitry in those affected by post-acute sequelae of SARS-CoV-2 infection.

Who could benefit from this research

Good fit: Ideal candidates include individuals who have experienced neuropsychiatric symptoms following a COVID-19 infection.

Not a fit: Patients who have not contracted COVID-19 or do not exhibit any neuropsychiatric symptoms may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for individuals suffering from long-term effects of COVID-19.

How similar studies have performed: Other research has shown promising results in understanding the neurological impacts of viral infections, suggesting that this approach could yield valuable insights.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions adverse sequelae of coronavirus diseaseadverse sequelae of coronavirus disease 2019
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.