Exploring brain function changes in people with long-term effects of COVID-19
Official title: Understanding Circuit Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection
Funded at Yale University · NIH-11023241 · Data updated 2026-11-12
This study is looking at how COVID-19 might affect your brain and mental health, like causing memory problems or anxiety, and it's for people who have had COVID-19 and want to understand their symptoms better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $797,157 |
| NIH project number | 1R01MH138347-01 |
| Project ID | NIH-11023241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals who have experienced neuropsychiatric symptoms following a COVID-19 infection.
✕Less likely to help
Patients who have not contracted COVID-19 or do not exhibit any neuropsychiatric symptoms may not benefit from this research.
What this research studies
This research investigates the neuropsychiatric symptoms experienced by individuals who have had COVID-19, such as cognitive impairment, anxiety, and autonomic dysfunction. By utilizing the resources of the NeuroCOVID Clinic and The COVID Mind Study at Yale, the research aims to understand how these symptoms are linked to changes in brain function. Participants will undergo neuroimaging and cognitive testing to identify biological markers associated with their symptoms. The goal is to provide a clearer understanding of the brain's circuitry in those affected by post-acute sequelae of SARS-CoV-2 infection.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for individuals suffering from long-term effects of COVID-19.
How similar studies have gone: Other research has shown promising results in understanding the neurological impacts of viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Constable, R Todd — Yale University
- Study coordinator: Constable, R Todd
Related research
Other NIH-funded projects on the same topics.
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How COVID-19 infection and genes may influence memory and dementia risk
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Maternal SARS-CoV-2 infection and its effects on placenta and child development
This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.
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How COVID-19 and genetics influence memory and dementia risk in older adults
This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.
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This project in Kenya checks how having had COVID-19 might influence the reactivation of latent tuberculosis in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.