Exploring brain function and development in Down syndrome and its link to Alzheimer's disease
Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome
This study is looking at how Down syndrome affects brain function and its possible link to Alzheimer's disease, using special techniques to explore brain cells and their interactions, so we can better understand these conditions and find new ways to help in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10108413 on NIH RePORTER |
What this research studies
This research investigates the complex effects of Down syndrome (DS) on brain function and its potential connection to Alzheimer's disease (AD). By utilizing advanced techniques like single nucleus RNA and ATAC-seq sequencing, the study aims to analyze the various brain cell types and their interactions, particularly focusing on how early developmental changes in DS may lead to cognitive dysfunctions and AD later in life. The research also involves creating cortical organoids from induced pluripotent stem cells (iPSCs) to better understand the underlying mechanisms at play. Through this comprehensive approach, the study seeks to uncover critical insights that could inform future treatments and interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Down syndrome, particularly those who may be experiencing early signs of cognitive decline or are at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who do not have any cognitive impairments related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential therapies for cognitive dysfunctions associated with Down syndrome and Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using advanced sequencing techniques to understand neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Rosenfeld, Michael G — University of California, San Diego
- Study coordinator: Rosenfeld, Michael G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.