Exploring brain connections using advanced electron microscopy techniques
BRAIN CONNECTS: Multi-Beam Transmission Electron Microscopy of Iteratively Milled Semi-Thick Tissue Sections
This study is exploring new ways to take super-detailed pictures of brain connections, which could help us understand how the brain works and lead to better treatments for neurological conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Paul Scherrer Institut Psi NIH-funded |
| Lab location | 1 site (Villigen Psi, Switzerland) |
| Project ID | NIH-10915485 on NIH RePORTER |
What this research studies
This research investigates innovative methods in electron microscopy to create detailed maps of neuronal connections in the brain. By utilizing multi-beam scanning and automated transmission electron microscopy, the project aims to overcome challenges related to sample preparation and imaging artifacts. Patients may benefit from insights gained about brain structure and function, which could inform future treatments for neurological conditions. The research involves cutting ultrathin tissue sections and imaging them to achieve high-resolution reconstructions of neuronal wiring.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in the biological mechanisms of brain function.
Not a fit: Patients with conditions unrelated to brain structure or function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain connectivity, potentially leading to improved treatments for neurological disorders.
How similar studies have performed: Previous research using similar electron microscopy techniques has shown promise in mapping neuronal connections, indicating a potential for success in this approach.
Where this research is happening
Villigen Psi, Switzerland
- Paul Scherrer Institut Psi — Villigen Psi, Switzerland (Active)
Researchers
- Principal investigator: Wanner, Adrian Andreas — Paul Scherrer Institut Psi
- Study coordinator: Wanner, Adrian Andreas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.