Exploring brain activity changes in Alzheimer's disease
Understanding the structural, functional, and prognostic implications of cortical excitability in Alzheimer's disease
This study is looking at how brain activity changes in people with early-stage Alzheimer's disease to help find signs that could show how the disease is progressing and possibly lead to better treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11084484 on NIH RePORTER |
What this research studies
This research investigates how changes in brain activity, specifically cortical excitability, relate to the progression of Alzheimer's disease. Using a technique called transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), the study aims to measure neuronal responses in patients with early-stage Alzheimer's. By understanding these responses, researchers hope to identify important markers that could predict disease progression and potentially guide future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-stage Alzheimer's disease who are experiencing cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without a diagnosis of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to assess and treat Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in using TMS-EEG to assess brain function in various neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Buss, Stephanie — Beth Israel Deaconess Medical Center
- Study coordinator: Buss, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.