Exploring bat stem cells to understand their unique biology
Bat pluripotent stem cells as a novel experimental system
This study is looking at special cells from bats to learn more about how they stay healthy and fight off diseases, which could help us understand their unique abilities better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906740 on NIH RePORTER |
What this research studies
This research investigates induced pluripotent stem cells (iPSCs) derived from bats, aiming to understand their unique biological characteristics. The team has already created the first bat iPSCs and found that they exhibit distinct metabolic and immune responses. By using CRISPR technology, the researchers plan to modify specific genes in these cells to further explore their immune responses and metabolic pathways. This work could provide insights into bat physiology and their remarkable resilience to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of immunity and metabolism, particularly in relation to zoonotic diseases.
Not a fit: Patients with conditions unrelated to immune response or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding immune responses and metabolic processes that may benefit human health.
How similar studies have performed: While research on bat biology is limited, the use of iPSCs and CRISPR technology has shown promise in other animal models, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Zwaka, Thomas P. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zwaka, Thomas P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.