Exploring autism's genetic links with miniature brain models
Modeling ASD-linked genetic mutations in 3D human brain organoids
['FUNDING_R01'] · HARVARD UNIVERSITY · NIH-11182638
This project explores how specific genetic changes linked to autism spectrum disorder affect early brain development using miniature brain models.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11182638 on ClinicalTrials.gov |
What this research studies
Autism spectrum disorder (ASD) is a condition where brain development can lead to an imbalance in how brain cells communicate. This project focuses on specific genetic changes, like those in the CHD8 gene, which are often found in people with ASD and can be linked to differences in head size. We use tiny, lab-grown brain models, called organoids, to observe how these genetic changes affect the development of different brain cells. Our previous work showed that these changes can cause certain brain cells to develop out of sync, potentially leading to issues in how brain circuits function. By understanding these early developmental problems, we hope to discover new ways to support individuals with ASD.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but focuses on understanding genetic causes of autism.
Not a fit: Patients not affected by the specific genetic mutations being studied, or those seeking immediate clinical interventions, may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the root causes of autism spectrum disorder, potentially guiding the development of new treatments or interventions.
How similar studies have performed: This project builds upon previous successful work by the same research team using similar brain organoid models to understand genetic links to autism.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARLOTTA, PAOLA — HARVARD UNIVERSITY
- Study coordinator: ARLOTTA, PAOLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autism Spectrum Disorder patient, Autistic Disorder