Exploring advanced technologies to understand human birth defects
Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects
This study is exploring how organs develop and what causes birth defects by looking closely at mouse embryos with genetic changes similar to those in humans, and it's designed to help researchers better understand these issues for families affected by congenital conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11003298 on NIH RePORTER |
What this research studies
This research aims to utilize cutting-edge technologies to investigate the biology of organ development and the causes of human structural birth defects. By employing techniques such as single-cell RNA sequencing and advanced 3D imaging, the researchers will analyze mouse embryos with mutations that relate to human conditions. This approach will help identify changes in gene expression and cell types during abnormal organ development, potentially revealing critical biological pathways involved in these defects. The collaboration between Seattle Children's Research Institute and the University of Washington enhances the depth of expertise in diagnosing congenital malformations.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with or at risk for structural birth defects.
Not a fit: Patients who do not have structural birth defects or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children with structural birth defects.
How similar studies have performed: Other research has shown success in using advanced imaging and genetic techniques to understand developmental biology, indicating a promising approach.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Beier, David R. — Seattle Children's Hospital
- Study coordinator: Beier, David R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.