Exploring a protein's role in preventing lung blood vessel malformations
Investigation of hepatic factor in pulmonary arteriovenous malformations
This study is looking at a protein called sVEGFR1 to see if it can help prevent abnormal blood vessel growth in the lungs of children with certain heart conditions, and it hopes to find better treatments for these young patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11057586 on NIH RePORTER |
What this research studies
This research investigates how a specific protein, soluble vascular endothelial growth factor receptor 1 (sVEGFR1), can help regulate the development of abnormal blood vessel formations in the lungs, particularly in children with certain heart conditions. By analyzing blood samples from patients, the study aims to understand how elevated levels of this protein might prevent pulmonary arteriovenous malformations (PAVMs). The research will involve laboratory tests using patient-derived tissues to explore the effects of sVEGFR1 on lung blood vessels. Ultimately, this work seeks to improve treatment options for young patients with congenital heart disease and related vascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old with univentricular congenital heart disease and a risk of pulmonary arteriovenous malformations.
Not a fit: Patients who do not have congenital heart disease or pulmonary vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat pulmonary arteriovenous malformations in children with congenital heart defects.
How similar studies have performed: Previous research has shown promising results in using similar approaches to regulate vascular growth and stability, indicating potential for success in this area.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Spearman, Andrew D — Medical College of Wisconsin
- Study coordinator: Spearman, Andrew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.