Exploring a new therapy for healing diabetic foot ulcers
Official title: Assessment of CCL3 Therapy in Diabetic Wound Care
Funded at University of California at Davis · NIH-11142273 · Data updated 2026-11-12
This study is looking at a new treatment to help heal diabetic foot ulcers by understanding how certain white blood cells work in these wounds, and it’s for people with diabetes who are dealing with slow-healing sores on their feet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 18, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $615,364 |
| NIH project number | 7R01DK135557-02 |
| Project ID | NIH-11142273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetic foot ulcers who are at risk of infection and complications due to their condition.
✕Less likely to help
Patients without diabetes or those who do not have diabetic foot ulcers may not benefit from this research.
What this research studies
This research investigates a novel therapy aimed at improving the healing of diabetic foot ulcers (DFUs), which are a significant complication of diabetes leading to amputations. The study focuses on understanding how neutrophils, a type of white blood cell, behave in diabetic wounds and how their impaired function contributes to infection and delayed healing. By examining the role of specific receptors on these cells, the research aims to identify ways to enhance their response to wounds, potentially leading to better healing outcomes for patients. Participants may receive a new treatment that targets these mechanisms to improve their wound healing process.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetic foot ulcers, reducing the risk of amputations and improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in enhancing neutrophil function in diabetic conditions, suggesting that this approach may lead to meaningful advancements in wound care.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Shafikhani, Sasha H — University of California at Davis
- Study coordinator: Shafikhani, Sasha H
Related research
Other NIH-funded projects on the same topics.
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Diabetic Foot Ulcer Healing Network at the University of Arizona
A NIH-supported project at the University of Arizona aims to improve healing of diabetic foot ulcers by studying biomarkers and running high-quality clinical trials.
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Understanding how skin layers coordinate healing after injury
Researchers are studying how different layers of adult skin coordinate rapid healing after injury to prevent infection and chronic wounds.
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Immunomodulatory therapy to speed up healing after oral cavity injuries in kids
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How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
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Understanding how skin cells exchange harmful chemicals to cause injury and wound repair
A research project aims to uncover how certain chemical agents damage human skin and what happens in the early stages of blistering and inflammation.
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Intestinal mucosal wound healing in humans
A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.