Exploring a new target to prevent protein changes in Parkinson's disease
Prevention of alpha-synuclein deSUMOylation as a Parkinson's therapeutictarget
This study is looking at how a process that affects a protein linked to Parkinson's disease might help protect brain cells, and it's for anyone interested in new ways to manage or prevent the symptoms of Parkinson's.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise State University NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project ID | NIH-11199863 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein modification process called SUMOylation in Parkinson's disease. Using mouse models, the study aims to understand how preventing the removal of SUMO groups from the protein alpha-synuclein could protect neurons from damage associated with Parkinson's. The researchers will explore the effects of a particular enzyme, SENP, which is involved in this process, and how it might be targeted to improve neuronal health. The ultimate goal is to identify new therapeutic strategies that could help in managing or preventing Parkinson's disease symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Parkinson's disease.
Not a fit: Patients with Parkinson's disease who are already in advanced stages of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect neurons and slow the progression of Parkinson's disease.
How similar studies have performed: While the specific approach of targeting SUMOylation in Parkinson's is novel, similar strategies in other neurodegenerative diseases have shown promise.
Where this research is happening
Boise, United States
- Boise State University — Boise, United States (Active)
Researchers
- Principal investigator: Kim, Yonghwan — Boise State University
- Study coordinator: Kim, Yonghwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.