Exploring a new target for treating pain
Sigma 2 Receptor (TMEM97): Investigating the Peripheral Role of this Novel Therapeutic Target for Pain
This study is looking at a new way to help people with both sudden and long-lasting pain by exploring a special receptor in the body that could lead to safer treatments than current opioids.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11010871 on NIH RePORTER |
What this research studies
This research investigates the Sigma 2 receptor (TMEM97) as a potential new target for treating both acute and chronic pain. The study aims to understand how this receptor functions in the body, particularly in relation to pain processing, by examining its cellular properties and the effects of specific ligands that interact with it. By using animal models, the research will explore how manipulating this receptor can alleviate pain without the high risks associated with current opioid treatments. The findings could lead to the development of safer pain management therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic or acute pain who are seeking alternative treatment options.
Not a fit: Patients who do not experience pain or have conditions unrelated to pain management may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, safer treatments for managing pain that minimize the risk of abuse and side effects.
How similar studies have performed: Previous studies have shown promising results in using the Sigma 2 receptor as a target for pain relief, indicating potential for success in this approach.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Hong, Veronica Minsu — University of Texas Dallas
- Study coordinator: Hong, Veronica Minsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.