Exploring a new target for treating chronic pain
Validation of Fibroblast-Derived PI16 as a Novel Target for pain Treatment
This study is looking at a protein called PI16 to see how it affects chronic pain, with the hope of finding new, safer treatments that can help people manage their pain without the risks of addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10795695 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called peptidase inhibitor 16 (PI16) in chronic pain management. Researchers have found that PI16 is present in specific cells around nerves and increases during neuropathic pain. By studying mouse models and human tissue samples, the project aims to understand how PI16 contributes to pain and whether it can be targeted for new treatments. The goal is to validate PI16 as a potential target for safe and effective pain relief without the addictive risks associated with opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain, particularly those with neuropathic pain conditions.
Not a fit: Patients with acute pain or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, non-addictive treatments for chronic pain.
How similar studies have performed: While the approach of targeting PI16 is novel, previous research has shown success in identifying new pain regulators, suggesting potential for breakthroughs in this area.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Shepherd, Andrew John — University of Tx Md Anderson Can Ctr
- Study coordinator: Shepherd, Andrew John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.