Exploring a new role of a protein in muscle metabolism
Official title: Identify a new non-canonical role of MEF2Da2 protein isoform in skeletal muscle metabolism
Funded at University of Houston · NIH-11131168 · Data updated 2026-11-12
This study is looking at a specific protein that helps our muscles work better, especially as we age or deal with muscle-related issues, to find ways to improve muscle health and function for adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $155,430 |
| NIH project number | 5R21AR083158-03 |
| Project ID | NIH-11131168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old, particularly those experiencing muscle decline due to aging or related metabolic disorders.
✕Less likely to help
Patients with acute muscle injuries or those under 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates the role of the MEF2Da2 protein isoform in skeletal muscle metabolism, particularly how alternative splicing affects muscle function and metabolism. The study aims to understand how changes in protein isoforms can influence muscle health, especially in the context of aging and muscle-related diseases. By examining the molecular mechanisms involved, the research seeks to uncover potential therapeutic targets for improving muscle function in adults. Patients may benefit from insights into how muscle metabolism can be optimized or restored.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing muscle health and function in aging adults and those with muscle-related conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of alternative splicing in muscle function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Houston
Houston, United States Active
Researchers
- Principal investigator: Singh, Ravi K. — University of Houston
- Study coordinator: Singh, Ravi K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.