Exploring a new method to assess retinal cell function using advanced imaging techniques
Investigating fundamental properties and clinical applications of the optoretinogram
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11046529
This study is looking at a new way to see how well the light-sensitive cells in your eyes are working, using special imaging technology to create detailed pictures of the retina, and it's for anyone with retinal diseases or those who have healthy eyes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11046529 on ClinicalTrials.gov |
What this research studies
This research investigates the optoretinogram (ORG), a novel optical assay designed to evaluate the function of photoreceptors in the human retina. By utilizing adaptive optics optical coherence tomography (AO-OCT), the study aims to create detailed 3D images of the retina at a cellular level, allowing for the detection of dysfunction in photoreceptors. The research will measure responses in both normal subjects and those with retinal diseases, focusing on how light stimuli affect the outer segments of photoreceptors. Through this approach, the study seeks to enhance our understanding of retinal diseases and their underlying mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with age-related macular degeneration or other retinal diseases, as well as healthy volunteers for comparison.
Not a fit: Patients with non-retinal related conditions or those who do not have access to the required imaging technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic techniques for retinal diseases, enabling earlier detection and better management of conditions like age-related macular degeneration.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for retinal assessment, suggesting that this approach may yield valuable insights into photoreceptor function.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONNAL, RAVI S. — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: JONNAL, RAVI S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age related macular disease