Exploring a new HIV prevention method for breastfeeding women in Botswana
Official title: Linking HIV Prevention and post-partum care: Safety, efficacy and feasibility of cabotegravir-LA PrEP in high-risk breastfeeding population in Botswana
Funded at Beth Israel Deaconess Medical Center · NIH-10676833 · Data updated 2026-11-12
This study is looking at a long-lasting injectable HIV prevention medication for breastfeeding women in Botswana to see if it’s safe and helps them stay protected from HIV while making it easier to get the care they need after having a baby.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 24, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2023 |
| Award (this year) | $586,400 |
| NIH project number | 5R01HD108047-03 |
| Project ID | NIH-10676833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are high-risk breastfeeding women in Botswana who have recently given birth.
✕Less likely to help
Patients who are not breastfeeding or who are not at high risk for HIV may not benefit from this research.
What this research studies
This research investigates the use of an injectable HIV prevention medication called cabotegravir-LA in high-risk breastfeeding women in Botswana. It aims to address challenges in adhering to traditional oral HIV prevention methods by providing a long-acting injectable alternative. The study will evaluate the safety of this medication during breastfeeding and explore effective ways to deliver HIV prevention services alongside post-partum care. By focusing on women during the immediate post-partum period, the research seeks to improve access to HIV prevention for those who are at increased risk.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of HIV among breastfeeding women and their infants.
How similar studies have gone: Previous research has shown promising results with injectable HIV prevention methods, indicating potential for success in this novel application.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Zash, Rebecca Marie — Beth Israel Deaconess Medical Center
- Study coordinator: Zash, Rebecca Marie
Related research
Other NIH-funded projects on the same topics.
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CAB-LA PrEP for breastfeeding women after delivery in Botswana
This study tests a long-acting HIV prevention shot for new mothers who are breastfeeding in Botswana to see if it prevents HIV safely and effectively.
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CAB-LA PrEP for new mothers: safer HIV prevention for breastfeeding women in Botswana
A study tests a long-acting HIV prevention injection for breastfeeding women who are at high risk of HIV in Botswana.
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Long-acting injectable HIV prevention for breastfeeding mothers
This project offers long-acting injectable cabotegravir to high-risk breastfeeding women starting at delivery, with follow-up through post-partum and baby-care clinics to prevent HIV.
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Long-acting injectable HIV prevention for breastfeeding new mothers
This project looks at whether a long-acting injectable HIV prevention shot (cabotegravir) given after childbirth can safely protect breastfeeding women at high risk of HIV.
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Harnessing male peer networks to boost HIV testing and PrEP use
A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.
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Harnessing men's peer networks to boost HIV self-testing and PrEP use
A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.