Exploring a new epigenetic marker in Parkinson's Disease
Investigating Histone 3 Dopaminylation in Parkinson's Disease
['FUNDING_FELLOWSHIP'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10996999
This study is looking at a new way that dopamine might affect brain proteins in people with Parkinson's Disease and dementia, hoping to find new treatments that could help slow down memory and movement problems.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10996999 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a novel epigenetic marker, dopaminylation, in Parkinson's Disease (PD) and its associated dementia. The study focuses on how dopamine modifies histone proteins, which may influence the progression of neurodegeneration. By understanding these mechanisms, the research aims to identify potential therapeutic targets that could slow down or prevent the onset of dementia in PD patients. The approach involves examining the biochemical processes in the brain that contribute to both movement and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's Disease, particularly those who may be at risk of developing dementia.
Not a fit: Patients with other forms of dementia unrelated to Parkinson's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Parkinson's Disease and its related dementia.
How similar studies have performed: Previous research has shown promise in exploring epigenetic modifications in neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, WINNIE — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CHEN, WINNIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia, Alzheimer's disease and related disorders, Alzheimer's disease or a related dementia, Alzheimer's disease or a related disorder, Alzheimer's disease or related dementia