Exploring a natural treatment for menopause-related estrogen deficiency
8-Prenylnaringenin: A Natural Therapy for Estrogen Deficiency
This study is looking at a natural compound from hops called 8-prenylnaringenin to see if it can safely help women going through menopause with issues like weight gain and inflammation, offering a friendly alternative to hormone replacement therapy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10769726 on NIH RePORTER |
What this research studies
This research investigates the use of 8-prenylnaringenin, a compound derived from hops, as a natural alternative to hormone replacement therapy for women experiencing menopause. The study aims to determine the safe and effective dosage of 8-PN to combat metabolic and inflammatory issues associated with estrogen deficiency, particularly focusing on obesity. Researchers will also identify which tissues respond best to this treatment and explore the underlying biological mechanisms. This approach seeks to provide a safer option for managing menopause-related health challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are post-menopausal women experiencing symptoms related to estrogen deficiency, such as weight gain and increased inflammation.
Not a fit: Patients who are pre-menopausal or those not experiencing estrogen deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a safe and effective natural therapy for women suffering from menopause-related metabolic and inflammatory issues.
How similar studies have performed: Previous research has shown promise in using phytoestrogens for managing menopause symptoms, suggesting potential success for this approach.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Enos, Reilly — University of South Carolina at Columbia
- Study coordinator: Enos, Reilly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.