Exploring a genetic immune disorder linked to B cell deficiency
Investigation of a Novel Inborn Error of Immunity with B Cell Deficiency
['FUNDING_R21'] · WASHINGTON UNIVERSITY · NIH-11000278
This study is looking into a genetic condition that makes it hard for your immune system to fight infections because it doesn't produce enough antibodies, and the researchers want to find out how this happens and discover new treatments to help improve your health.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11000278 on ClinicalTrials.gov |
What this research studies
This research investigates a specific genetic condition known as an inborn error of immunity, which affects the immune system's ability to produce antibodies. Patients with this condition experience recurrent infections due to a deficiency in B cells, which are crucial for fighting off infections. The research aims to understand the genetic mechanisms behind this deficiency and to identify potential targeted therapies. By studying the signaling pathways and genetic factors involved in B cell maturation, the researchers hope to develop new treatments that can improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with an autosomal dominant antibody deficiency and recurrent infections due to B cell dysfunction.
Not a fit: Patients without a genetic basis for their immune issues or those with different types of immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that enhance the immune response in patients with B cell deficiencies.
How similar studies have performed: Previous research on inborn errors of immunity has led to significant advancements in understanding immune disorders and developing effective treatments.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COOPER, MEGAN ANNE — WASHINGTON UNIVERSITY
- Study coordinator: COOPER, MEGAN ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.