Exploring a genetic immune disorder linked to B cell deficiency
Official title: Investigation of a Novel Inborn Error of Immunity with B Cell Deficiency
Funded at Washington University · NIH-11000278 · Data updated 2026-11-12
This study is looking into a genetic condition that makes it hard for your immune system to fight infections because it doesn't produce enough antibodies, and the researchers want to find out how this happens and discover new treatments to help improve your health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 12, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $188,544 |
| NIH project number | 5R21AI180271-02 |
| Project ID | NIH-11000278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with an autosomal dominant antibody deficiency and recurrent infections due to B cell dysfunction.
✕Less likely to help
Patients without a genetic basis for their immune issues or those with different types of immune deficiencies may not benefit from this research.
What this research studies
This research investigates a specific genetic condition known as an inborn error of immunity, which affects the immune system's ability to produce antibodies. Patients with this condition experience recurrent infections due to a deficiency in B cells, which are crucial for fighting off infections. The research aims to understand the genetic mechanisms behind this deficiency and to identify potential targeted therapies. By studying the signaling pathways and genetic factors involved in B cell maturation, the researchers hope to develop new treatments that can improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that enhance the immune response in patients with B cell deficiencies.
How similar studies have gone: Previous research on inborn errors of immunity has led to significant advancements in understanding immune disorders and developing effective treatments.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cooper, Megan Anne — Washington University
- Study coordinator: Cooper, Megan Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.