Expanding the CALERIE network for aging research
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
This project keeps and grows a research network that uses long-term calorie‑restriction data and biological samples to learn how aging works in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11223602 on NIH RePORTER |
What this research studies
This effort maintains and expands the CALERIE resource, which includes detailed health measurements and stored blood/tissue samples from adults who took part in a two‑year calorie‑restriction trial. Researchers share and add new analyses, including genetic and other “omics” tests, using those samples and linked clinical data. The project also brings in a 15‑year follow‑up (the CALERIE Legacy Study) and recent pilot projects to look at longer‑term effects. It supports pilot grants and early‑career investigators so new studies can use the data and samples.
Who could benefit from this research
Good fit: Adults who previously took part in CALERIE or other calorie‑restriction studies, or adults willing to join long‑term aging follow‑up and provide health information and biospecimens, are the best matches.
Not a fit: People seeking an immediate clinical therapy or those unable or unwilling to provide follow‑up data or biological samples are unlikely to get direct personal benefit from participation.
Why it matters
Potential benefit: If successful, the work could identify biological markers or pathways of aging that point to ways to delay age‑related decline or target treatments.
How similar studies have performed: The original CALERIE Phase 2 trial and resulting analyses have produced notable publications and expanded omics data, but longer‑term effects and broad clinical implications are still being explored.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Huffman, Kim M. — Duke University
- Study coordinator: Huffman, Kim M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.