Exosomes from damaged hearts affect immune responses after heart attacks
TNFR1 Expressing Exosomes are Critical Mediators of Pathological Immune Activation in the Spleen post-Myocardial Infarction
['FUNDING_R01'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-10902115
This study is looking at how tiny particles from injured heart tissue can affect the immune system after a heart attack, which could help us understand how to improve healing and recovery for people who have had one.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-10902115 on ClinicalTrials.gov |
What this research studies
This research investigates how exosomes, tiny vesicles released from damaged heart tissue, influence immune activation following a heart attack. By studying the communication between the heart and immune system, the researchers aim to understand how these exosomes carry signals that may affect healing and recovery. The approach involves using animal models to track the movement and effects of these exosomes on immune cells in the spleen and bone marrow. This could lead to new insights into how the body responds to heart injury and how to improve recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
Not a fit: Patients who have not had a heart attack or those with chronic heart conditions unrelated to acute myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart healing and improve outcomes for heart attack patients.
How similar studies have performed: Other studies have shown that exosomes play a significant role in intercellular communication and immune responses, suggesting that this approach has potential for success.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANSAL, SHYAM SUNDER — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: BANSAL, SHYAM SUNDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.