Exercise program to improve health in lung transplant candidates
Official title: XFIT: An Exercise-based Frailty Intervention in Lung Transplant Candidates
Funded at University of California, San Francisco · NIH-10952296 · Data updated 2026-11-12
This study is testing a special exercise program designed to help people waiting for a lung transplant feel stronger and healthier, so they can have better outcomes before and after their surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $452,181 |
| NIH project number | 1R61HL169183-01A1 |
| Project ID | NIH-10952296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals on the lung transplant waiting list who are identified as frail.
✕Less likely to help
Patients who are not awaiting lung transplantation or those who do not exhibit signs of frailty may not benefit from this research.
What this research studies
This research focuses on developing an exercise-based intervention aimed at reducing frailty in patients awaiting lung transplants. It recognizes that many candidates experience frailty, which can lead to higher risks of complications and mortality. The program will involve tailored physical activity and lifestyle modifications to enhance physical strength and overall health. By addressing frailty through exercise, the research aims to improve patient outcomes before and after transplantation.
Why it matters
Potential benefit: If successful, this research could significantly improve the health and survival rates of lung transplant candidates.
How similar studies have gone: Previous research has shown that exercise interventions can effectively reduce frailty in older adults, suggesting a promising approach for lung transplant candidates.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Singer, Jonathan Paul — University of California, San Francisco
- Study coordinator: Singer, Jonathan Paul
Related research
Other NIH-funded projects on the same topics.
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Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
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Exercise program to reduce frailty in people awaiting lung transplant
A tailored exercise and lifestyle program to help people who are frail while waiting for a lung transplant get stronger and more active.
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Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
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Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
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The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.