Exercise before surgery to reduce inflammation
Official title: Preoperative exercise therapy for surgery triggered inflammation
Funded at Feinstein Institute for Medical Research · NIH-10900811 · Data updated 2026-11-12
This study is looking at how doing exercise before major liver surgery can help reduce inflammation and liver damage, making recovery easier for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | August 16, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $340,601 |
| NIH project number | 5R01GM137203-05 |
| Project ID | NIH-10900811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for major liver surgery who are physically able to participate in an exercise program.
✕Less likely to help
Patients who are not undergoing liver surgery or those with severe physical limitations may not benefit from this research.
What this research studies
This research investigates how preoperative exercise therapy can help reduce inflammation and liver damage in patients undergoing major liver surgery. By engaging in exercise before their procedure, patients may experience improved recovery outcomes due to changes in immune cell function and a reduction in inflammatory responses. The study utilizes advanced techniques like single-cell RNA sequencing to understand how exercise alters the body's response to surgery. The goal is to establish a beneficial exercise regimen that can be recommended to patients prior to surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing liver surgery.
How similar studies have gone: Previous research has shown that preoperative exercise can positively impact recovery in surgical patients, suggesting that this approach may be effective.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Huang, Hai — Feinstein Institute for Medical Research
- Study coordinator: Huang, Hai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.