Exercise before surgery helps reduce liver inflammation
Preoperative exercise therapy triggers trained immunity in KCs via cholinergic anti-inflammatory pathway
['FUNDING_R01'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-11100211
This study is looking at how doing exercise before liver surgery can help boost your immune system and reduce inflammation, making it easier for you to recover afterward.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-11100211 on ClinicalTrials.gov |
What this research studies
This research investigates how preoperative exercise therapy (PET) can enhance the immune response in the liver by activating specific immune cells known as Kupffer cells. The study utilizes a specialized treadmill to measure the effects of exercise on these cells and their ability to reduce inflammation during liver surgery. By understanding the mechanisms behind this process, the research aims to improve recovery outcomes for patients undergoing major abdominal surgeries. Patients who participate will engage in exercise regimens designed to optimize their immune function before surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for major abdominal surgeries, particularly those involving the liver.
Not a fit: Patients who are not undergoing liver surgery or who have contraindications to exercise may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing liver surgery.
How similar studies have performed: Previous research has shown that preoperative exercise can positively influence surgical outcomes, suggesting a promising avenue for further exploration in this area.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, HAI — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: HUANG, HAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.