Exercise before surgery helps reduce liver inflammation
Official title: Preoperative exercise therapy triggers trained immunity in KCs via cholinergic anti-inflammatory pathway
Funded at Feinstein Institute for Medical Research · NIH-11100211 · Data updated 2026-11-12
This study is looking at how doing exercise before liver surgery can help boost your immune system and reduce inflammation, making it easier for you to recover afterward.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | August 16, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $215,000 |
| NIH project number | 3R01GM137203-05S1 |
| Project ID | NIH-11100211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for major abdominal surgeries, particularly those involving the liver.
✕Less likely to help
Patients who are not undergoing liver surgery or who have contraindications to exercise may not benefit from this research.
What this research studies
This research investigates how preoperative exercise therapy (PET) can enhance the immune response in the liver by activating specific immune cells known as Kupffer cells. The study utilizes a specialized treadmill to measure the effects of exercise on these cells and their ability to reduce inflammation during liver surgery. By understanding the mechanisms behind this process, the research aims to improve recovery outcomes for patients undergoing major abdominal surgeries. Patients who participate will engage in exercise regimens designed to optimize their immune function before surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing liver surgery.
How similar studies have gone: Previous research has shown that preoperative exercise can positively influence surgical outcomes, suggesting a promising avenue for further exploration in this area.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Huang, Hai — Feinstein Institute for Medical Research
- Study coordinator: Huang, Hai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.