Exercise before surgery helps reduce liver inflammation
Preoperative exercise therapy modulates hepatic neutrophil extracellular trap formation
This study is looking at how doing exercise before major liver surgery might help your immune system work better and reduce inflammation, which could lead to a smoother recovery and better results after the operation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11057257 on NIH RePORTER |
What this research studies
This research investigates how preoperative exercise therapy can influence the formation of neutrophil extracellular traps (NETs) in patients undergoing major liver surgery. By focusing on the immune response, the study aims to understand how exercise can mitigate liver damage and inflammation caused by ischemia and reperfusion during surgery. Patients will engage in a structured exercise program before their surgical procedure, and researchers will monitor changes in immune cell behavior and inflammatory markers. The goal is to enhance recovery and improve surgical outcomes through exercise.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for major liver surgery who are able to participate in a preoperative exercise program.
Not a fit: Patients who are not undergoing liver surgery or those unable to participate in exercise due to medical restrictions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing liver surgery.
How similar studies have performed: Previous research has shown that preoperative exercise can positively impact recovery in surgical patients, indicating a promising approach in this area.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Huang, Hai — Feinstein Institute for Medical Research
- Study coordinator: Huang, Hai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.