Exercise before surgery helps reduce liver inflammation
Official title: Preoperative exercise therapy modulates hepatic neutrophil extracellular trap formation
Funded at Feinstein Institute for Medical Research · NIH-11057257 · Data updated 2026-11-12
This study is looking at how doing exercise before major liver surgery might help your immune system work better and reduce inflammation, which could lead to a smoother recovery and better results after the operation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | August 16, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $84,018 |
| NIH project number | 3R01GM137203-05S2 |
| Project ID | NIH-11057257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for major liver surgery who are able to participate in a preoperative exercise program.
✕Less likely to help
Patients who are not undergoing liver surgery or those unable to participate in exercise due to medical restrictions may not benefit from this research.
What this research studies
This research investigates how preoperative exercise therapy can influence the formation of neutrophil extracellular traps (NETs) in patients undergoing major liver surgery. By focusing on the immune response, the study aims to understand how exercise can mitigate liver damage and inflammation caused by ischemia and reperfusion during surgery. Patients will engage in a structured exercise program before their surgical procedure, and researchers will monitor changes in immune cell behavior and inflammatory markers. The goal is to enhance recovery and improve surgical outcomes through exercise.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing liver surgery.
How similar studies have gone: Previous research has shown that preoperative exercise can positively impact recovery in surgical patients, indicating a promising approach in this area.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Huang, Hai — Feinstein Institute for Medical Research
- Study coordinator: Huang, Hai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.