Examining the oral microbiome in young children affected by HIV in Kenya
Official title: Longitudinal Oral Microbiome for HIV/HEU/HUU Children Aged 3-4 in Western Kenya
Funded at University of California Los Angeles · NIH-10837955 · Data updated 2026-11-12
This study is looking at how the bacteria in the mouths of young children, ages 3 to 4, changes based on whether they are HIV-positive, have been exposed to HIV but are not infected, or have never been exposed to HIV, to help improve their oral health and care.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $157,500 |
| NIH project number | 1R03DE033631-01 |
| Project ID | NIH-10837955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 3-4 years who are HIV-positive, HIV-exposed uninfected, or HIV-unexposed uninfected.
✕Less likely to help
Patients outside the age range of 3-4 years or those not affected by HIV may not benefit from this research.
What this research studies
This research investigates how the oral microbiome changes in children aged 3-4 who are either HIV-positive, HIV-exposed uninfected (HEU), or HIV-unexposed uninfected (HUU). By collecting oral swab samples from 360 children over a year, the study aims to understand the differences in bacterial communities among these groups. The findings could help identify oral health risks and inform better healthcare strategies for these vulnerable populations. The research focuses on the critical period of primary dentition, which is essential for understanding oral health development.
Why it matters
Potential benefit: If successful, this research could lead to improved oral health interventions for children affected by HIV, potentially reducing mortality and morbidity.
How similar studies have gone: Previous research has shown that understanding the oral microbiome can lead to significant insights into health outcomes, suggesting potential success for this approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Wang, Yan — University of California Los Angeles
- Study coordinator: Wang, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.