Examining the link between the microbiome and heart disease in people with HIV
Official title: Multiomics analysis of the microbiome and subclinical cardiovascular disease in HIV infection
Funded at Albert Einstein College of Medicine · NIH-11003733 · Data updated 2026-11-12
This study is looking at how the bacteria in your mouth might affect heart health for people living with HIV, and it will compare results from both HIV-positive and HIV-negative individuals to see what differences there are.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $165,639 |
| NIH project number | 5K01HL169019-02 |
| Project ID | NIH-11003733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are HIV-positive and those who are HIV-negative, particularly those with or at risk for cardiovascular disease.
✕Less likely to help
Patients who do not have HIV or cardiovascular disease may not benefit from the findings of this research.
What this research studies
This research investigates how the microbiome, particularly in the mouth, may influence cardiovascular disease in individuals living with HIV. By analyzing saliva samples and using advanced sequencing techniques, the study aims to identify specific bacteria and their functions that could be associated with heart health. The research will involve both HIV-positive and HIV-negative participants, allowing for a comparative analysis. The findings could lead to a better understanding of how microbiome changes affect cardiovascular health in HIV patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between the microbiome and various health conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Wang, Zheng — Albert Einstein College of Medicine
- Study coordinator: Wang, Zheng
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients
This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.
-
Understanding how age-related blood changes affect heart disease risk in people with HIV
This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.
-
Blood cell mutations, chromosome changes, and heart disease in people living with HIV
This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.
-
Clonal blood mutations and chromosome changes linked to heart disease in people with HIV
Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.
-
How Lp(a) levels affect heart and artery disease risk in people with HIV
This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.